摘要
7-氯-6-氟-4-羟基喹啉-3-羧酸乙酯(3)的乙基化使用无水 K_2CO_3或无水 Na_2CO_3作脱酸剂,用HPLC 法测定 N-及 O-乙基化物(2与1)的相对含量。考察了溶剂中水份对2和1生成比例的影响。
Ethyl 7-chloro-6-fluoro-4-hydroxyquinoline-3-carboxylate (3) wassubjected to ethylation with ethyl bromide in different solvents (including hydrousDMF) with anhydrous K_2CO_3 or Na_CO_3 to give mixed N-and O-ethylated pro-ducts(2 and 1).The ratio betwean 2 and 1 in the mixture was investigated byHPLC method.The result indicated that the relative content of 1 was signifi-cantly reduced with Na_2CO_3 and not affected by the water contained in DMF.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1993年第7期289-290,共2页
Chinese Journal of Pharmaceuticals
关键词
诺氟沙星
合成中间体
喹啉衍生物
norfloxacin
synthesis
intermediate
quinoline derivative
