摘要
利用诺氟沙星的两性性质将其制成酸式盐与碱式盐溶液,再使等当量迅速混合,形成中性水合物微晶,并选得中和反应时的最佳浓度为10%,最佳温度为40℃,获得的针状水合物微晶长约7～11μm,符合软膏粒度要求。将此微晶以 o/w 型乳膏基质配制成无刺激性的中性乳膏,它具有较好的稳定性,基质对药效也无干扰。本法同样适用于环丙沙星乳膏的制备。
The amphoteric character of norfloxacin and ciprofloxacin was used
to prepare their microcrystalline creams.Thus,for example,norfloxacin was di-
vided into two equal parts,the solutions of its salts with acid or alkali were pre-
pared separately from the two parts of which the concentrations were about 10%.
At 40℃,the two solutions were mixed under vigorous stirring,the fine needle
crystals formed with 8～16μm lenth was used to prepare cream,which was non
irritating,stable and highly potent.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1993年第7期303-306,共4页
Chinese Journal of Pharmaceuticals
关键词
诺氟沙星
环丙沙星
制备
乳膏剂
norfloxacin
ciprofloxacin
cream
preparation
microcrystalline
