胃癌危险因素的病例对照研究

A Case-control Study on Risk Factors of Gastric Cancer

目的 探索湖南省胃癌发生的危险因素和保护因素 ,为综合防治提供流行病学依据。方法 采用 1:1配对的病例对照研究 ,对 175对病例及对照进行饮食及生活行为问卷调查。用比值比(OR)来估计各危险因素与胃癌的联系强度 ,采用Logistic回归进行单因素和多因素分析 ,筛选出胃癌的危险因素。结果 影响胃癌发生的主要危险因素有 :饮酒 (OR =1.5 8,95 %CI1.18～ 2 .13)、饮食不规律 (OR =2 .0 0 ,95 %CI 1.34～ 3.10 )、高盐饮食 (OR =1.82 ,95 %CI 1.2 1～ 2 .74 )等 ;饮绿茶 (OR =0 .4 7,95 %CI 0 .2 6～ 0 .85 )是胃癌发生的保护因素。结论 纠正不良的饮食及生活行为 。

Objective To search the risk and protective factors of gastric cancer in Hunan province, and to offer epidemiologic information for comprehensive prevention and treatment of gastric cancer.Methods A 1:1 matched case-control study was conducted 175 patients with gastric cancer and 175 controls were surveyed by questionnaire. ondiet and life Correlation between all the risk factors and gastric cancer was evaluated by the odd ratio (OR). Univariate and multivariate analysis by logistic regression model was to choose significant risk factorsResults The main risk factors on gastric cancer include alcohol drinking (OR=1.58,95% CI1.18～2.13)?irregular diet (OR=2.00,95% CI 1.34～3.10)?intake of high salt diets (OR=1.82,95% CI 1.21～2.74),etc. Green tea (OR=0.47,95% CI 0.26～0.85) was protectivefactors. Conclusion To dispel bad habits of diet and life-style, and to drink green tea frequently may be able to reduce incidence rate of gastric cancer.