多发性肌炎及皮肌炎患者肌肉组织中免疫球蛋白的沉积

Immunoglobulin Deposition in Skeletal Muscle in Polymyositis and Dermatomyositis

应用免疫酶标技术,对22例多发性肌炎/皮肌炎(PM/DM)和19例非肌炎患者肌肉组织中的免疫球蛋白和补体(Ig/C)进行检测。结果显示:肌炎组IgG的阳性率为72.7%,高于非肌炎组的31.6%;IgM和C_3在肌炎组的阳性率均为18.1%,非肌炎组则为阴性。Ig/C主要沉积在毛细血管壁和小血管内膜上,偶见变性肌纤维和单核细胞着色。Ig/C沉积提示免疫反应在PM/DM的发病机理中占有重要地位。该检测对PM/DM的诊断及与肌营养不良等肌病的鉴别诊断有一定帮助。

An immunohistochemical study was conducted using the biotin avidin technique in 22 muscle specimens from PM/DM patients and 19 control subjects. Deposition of IgG, IgM or C_3 in the wall of capillaries and small vessels was demonstrated in 72.7％ of PM/DM patients and in 31.6％ of those with other neuromuscular disorders. This finding supports the contention that immunoglobulins and complement-mediated immunoreaction may play an important role in PM/DM pathogenesis.