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Ⅰ型菌毛大肠杆菌在小鼠膀胱炎发病中的致病机理

Study on Infectious Mechanism of Type 1 Fimbriated Escherichia coli in Experimental Cystitis of Mice
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摘要 用电子显微镜对Ⅰ型菌毛大肠杆菌引起的小鼠试验性膀胱炎发病过程进行了观察.发现在膀胱上皮表层上皮细胞部分剥离的情况下,注入膀胱的Ⅰ型菌毛大肠杆菌可发生附着并引致炎症发生。结果表明Ⅰ型菌毛大肠杆菌具有引起膀胱炎的致病性,而膀胱表层上皮细胞的剥离则可能是膀胱炎发病的重要起因之一. The course of experimental cystitis in mice with Escherichia coli was studied by electron microscopy.The inoculated E.coli did not adhere to the intact bladder epithelium.However,when the mouse bladder was treated with trypsin, superficial cells were exfoliated,and the inoculated type 1 fimbriated E. coli adhered to the exposed intermediate cells and caused cystitis.The nonfimbriated E.coli showing no adherence to the superficial cells or intermediate cells and failed to cause cystitis.The present study demonstrated that the type 1 fimbriated E.coli play a role in causing cystitis,and the bladder superficial cells play a role in resisting the adherence of E.coli.The removal of superficial cells is essential for the adhesion and colonization of type 1 fimbriated E.coli onto the bladder epithelium in vivo.
出处 《中国医学科学院学报》 CAS CSCD 北大核心 1993年第4期250-254,共5页 Acta Academiae Medicinae Sinicae
关键词 大肠杆菌 Ⅰ型菌毛 膀胱炎 病理 escherichia coli type 1 fimbriae cystitis superficial cells
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