唇腺的年龄性改变及其在Sjgren综合征诊断中的意义

Age-related Changes of Human Lip Salivary Glands and Their Values in the Diagnosis of Sjogren Syndrome

对30例符合标准的尸检唇腺和21例Sjǒgren综合征唇腺活检标本进行组织学观察,发现导管扩张、脂肪组织聚积,腺泡萎缩呈导管样退化、间质纤维化及淋巴细胞浸润为唇腺的年龄性改变。用唇腺活检诊断Sjǒgren综合征,对<60岁的患者,除淋巴细胞浸润≥1灶/4mm^2这一主要标准外,导管扩张、脂肪组织聚积及腺泡萎缩也应作为参考指标;对≥60岁的患者,则应注意唇腺的年龄性改变。免疫组化染色显示年龄性改变和Sjǒgren综合征唇腺组织局部合成免疫球蛋白(IgG、IgA、IgM)的能力不同,IgG和IgM比IgA相对增高有助于Sjǒgren综合征的诊断.

The lip salivary glands (LSG) from 30 non-autoimmune disease postmortem subjects and 21 biopsies of Sjogren syndrome patients were examined histopathologically. Acinar atrophy, duct dilation, fat tissue hyperplasia, fi-brosis and lymphocytic infiltration (including foci) were found to be agerela-ted changes of LSG, and indicate that attention should be paid to distinguishing such aging changes from Sjogren syndrome's histopathological changes,especially in patients over 60 years old. The immunohistological study showed some differences in IgG,IgM and IgA synthesis in the LSG between SS and age-related subjects.