羟乙桂胺镇痛作用和致依赖性实验研究

EXPERIMENTAL STUDY ON ANALGESIC EFFECT AND DEPENDENCE POTENTIAL OF IDROCILAMIDE

小鼠扭体试验和热板试验表明羟乙桂胺的镇痛作用与剂量相关,小鼠口服本品的镇痛作用其ED_(50)为62mg/kg。以吗啡作对照对小鼠进行的6周试验,说明羟乙桂胺并不产生身体依赖性,用烯丙吗啡催瘾未见戒断症状。

The median analgesic dose (ED_(50)) of idrocilamide in mice was62mg/kg(po)according to hot plate methed.On the basis of tailerection test for6 weeks in mice with morphine as control idrocilamide did not show physicaldependence.No withdrawal symptoms occurred in the nalorphine precipitationtest.