摘要
试验了乙酸钠、甲硫氨酸、乙醇、正丙醇、正丁醇和豆油对螺旋霉素链霉菌 SPM^r-248发酵的影响。结果表明在发酵培养48h 时补入1.0%豆油可使螺旋霉素摇瓶发酵效价提高49%。在30 m^3发酵罐上应用该工艺,发酵效价与原工艺比较可提高30%,发酵指数提高18.9%。
The effect of sodium acetate,methionine,ethanol,n-propanol,n-butanol and soybean oil during the process of spiramycin fermentation byStreptomyces spiramyceticus cultured on complex medium was studied.It wasfound that there was a little increase in spiramycin productivity by addition ofsodium acetate,ethanol,n-propanol,or n-butanol after 48h of cultivation and alarge increase by addition of soybean oil either at the beginning or after 48h ofcultivation.Spiramycin productivity could be increased 49% by addition of 1%oil after 48h of cultivation.This technology had been used in 30m^3 fermenters.The potency and fer-mentation index of spiramycin were increased 30.2% and 18.9%,respectively.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1993年第8期337-339,共3页
Chinese Journal of Pharmaceuticals
关键词
螺旋霉素
发酵
豆油
spiramycin
fermentation
soybean oil
