摘要
刺参酸性粘多糖(SJAMP)明显抑制小鼠S180及乳腺癌细胞DNA的合成,对荷瘤小鼠正常肝细胞DNA的合成则具促进作用。以^(35)S-SJAMP进行了小鼠体内的吸收、分布、排泄及药物动力学研究。
~3H-TdR incorporation test showed that SJAMP inhibited obviously DNA synthesis of S180 and breast cancer cells, promoted DNA synthesis of hepatic cells. The metabolism study indicated that it conformed to the open two-comoartment model.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1993年第9期405-408,共4页
Chinese Journal of Pharmaceuticals
关键词
刺参
酸性粘多糖
DNA
药代动力学
acidic mucopolysaccharide
Stichopus japonicus
DNA synthesis
pharmacokinetics
metabolism
