急性肾炎合剂治疗小儿急性肾炎临床研究

Clinical and Experimental Study on Effects of Ji Shen Mixture for Infantile Acute Glomerulonephritis

采用中药急性肾炎合剂治疗小儿急性肾炎33例,并与西药组31例和正常组34例对比。结果显示急性肾炎脂质过氧化物(LPO)、谷胱甘肽过氧化物酶(GSH-Px)与正常组比较有非常显著差异(P<0.001),而超氧化物歧化酶(SOD)则无差异(P>0.5)。经治疗后LPO降低,GSH-Px增高(P<0.001),且中药组疗效优于西药组(P<0.05)。提示本方具有较强的抗自由基作用。患儿前列腺素稳定代谢产物6-K-PGF_2降低,TXB_2升高,TXB_2/6-K-PGF_1比值升高,与正常组比均有非常显著差异(P<0.001)。治疗后TXB_2下降(P<0.01),6-K-PGF_(1α)升高(P<0.05),TXB_2/6-K-PGF_(1α)下降(P<0.01),且中药组疗效优于西药组(P<0.01);另外中药组患儿血尿和蛋白尿阴转率明显优于西药组(P<0.005)。

33 cases of acute glomerulonephritis treated with Ji Shen Mixture (JSM) were studied with 31 cases treated with Western medical therapy (WM) for comparison and 34 healthy subjects as controls. The levels of lipo-peroxide (LPO), glutathione peroxidase (GSH--Px), superoxide dismutase (SOD), theromboxane B_2 (TXB_2), 6-keto-PGF_1α and TXB_2/6-keto-PGF_1α ratio were examined before and after tfeatffient. Compared with healthy controls, the levels of LPO, TXB_2 TXB_2/6 -keto-PGF_1α of patients increased and that of GSH-Px, 6-keto-PGF_1αdecreased significantly, whereas SOD activity had no significant difference. After treatment, the level of LPO reduced and GSH-Px activities raised significantly, but the effect of JSM group was better than that of WM group. It indicated that JSM was more effective in clearing the free radicals. The TXB_2, TXB_2/ 6-keto-PGF_1α dropped and 6-keto-PGF_1α elevated significantly after treatment, the effects of JSM wer markedly better than those of WM. Furthermore, JSM was more potent in raising the clearing rate of hematuria and Proteinuria.