310例血瘀证患者血小板功能与中医辨证关系的临床研究

Clinical Study on Relationship of TCM Syndrome and Blood Platelet Function in 310 Cases of Blood Stasis

本研究以310例血瘀证患者为观察对象,以血小板计数、体积和血小板粘附、聚集功能以及血浆TXB_2、6-Keto-PGF_(1α)含量为观测指标,探讨血小板功能与血瘀证的中医辨证的关系。结果表明:血瘀证患者血小板聚集功能亢进;不同病因所致血瘀证,以气虚血瘀者血小板聚集率明显高于正常(P<0.001);不同病住血瘀证,以心气虚血瘀证血小板聚集功能明显增强,且血浆TXB_2含量明显升高,与对照组相比,有显著性差异(P<0.05)。

310 patients (153 male, 157 female) of Blood Stasis were divided into various groups by Syndrome Differentiation of TCM and 35 healthy subjects were taken as control. The relationship of TCM Syndrome and function of blood platelet were studied with blood platelet counting, its volume, adherence and aggregation, plasma thromboxane B_2 (TXB_2) and 6-keto-prostaglandin F_1α(6k-PGF_1α) as indeces of observation. The results were: (1) Blood platelet aggregation of Blood Stasis patients was higher than that in control (P> 0.001). (2) There were some differences of platelet aggregation among different TCM Syndromes. Platelet aggregation of Blood Stasis patients with Qi Deficiency was higher than that with other Syndromes significantly, and the aggregating rate in those patients was higher than that in control (P< 0.05). (3) The platelet aggregation and TXB2 of patient with Heart Qi Deficiency were significantly higher than those of the control (P< 0.05, P< 0.001), and they were also higher than of other groups of blood stasis patient with Spleen, Lung or Kidney Qi Deficiency.