我国女性乳腺癌多原发灶的前瞻性病理学研究

Multicontricity in Chinese Female Breast with Carcinoma. A Histopathologcial Study by Whole Organ Sectioning

应用全乳腺次连续切片方法,对236个女性乳腺癌标本进行研究。本组乳腺癌多原发灶发生率为19.9％(47/236)。76％多原发灶的直径≤1cm,70.7％为非浸润性癌。83％的多原发灶分布于主原发癌相邻或相同象限。双侧原发乳腺癌、阳性肿瘤家族史、囊性增生病和/或导管上皮不典型增生的程度与多原发灶发生关系密切;主原发癌为乳头状瘤病癌变、导管癌早期浸润、粘液癌、腺癌或ER阳性者,较多出现多原发灶,而髓样癌、硬癌及大汗腺样癌则缺乏多原发灶。

The multicentricity has been studied by whole organ subserial section in 236 mastectomy specimens of female breast carcinoma. Multicentricity has been demonstrated in 47 breasts, with an incidence rate of 19.9％, and con- sisted of 75 multiple primary foci, 76% of which the foci measuring≤1. 0cm and in 70. 7% there was no evidence of in- vasion revealed. 83% of the multiple primary foci were distributed in the neighboring or same quadrant of the main prima- ry carcinoma. Some factors were found prone to develop multiple primary foci, such as bilateral breast cancer, positive family history, high grade of cystic hyperplasia and/or ductal atypical hyperplasia, background of papillomatosis, intra- ductal carcinoma with early infiltration, mucinous carcinoma, adenocarcinoma and positive of ER. The multicentricity was not found in medullary carcinoma, scirrhous carcinoma or apocrine carcinoma.