健脾补肾中药对肿瘤成因多阶段学说中起始和启动的影响

Effect of Chinese Herbs for Invigorating the Spleen and Tonifying the Kidney on Initiation and Promotion of Multiple Step Theory of Tumor Formation

本实验以“细胞突变试验”,“细胞介导突变试验”作为肿瘤成因多阶段学说的起始阶段的模型,观察中医中药对它们的影响。结果提示:白术,太四君汤,仙茅,仙灵脾等健脾补肾中药具有反突变作用;太四君汤,四君子汤,枸杞子等中药具有反启动作用;从而说明某些中药对肿瘤成因多阶段学说中的起始与启动阶段有明确的阻断作用。

The paper reported the effect of Chinese herbs on initiation and promotion of multiple step theory of tumor formation based on the model of cell mutation test and cell mediated mutation test. The results showed that Rhizoma Atraetylodis Maeroeephalae, Decoction Taisijun, Rhizoma Curculiginis, Herba Epimedii had antimutation effects and Decoction Taisijun, Decoction Sijunzi, Fructus Lycii etc. had effect against initiation. It therefor showed that some Chinese herbs had blocking effect on the steps of initiation and promotion.