食物对环丙沙星生物利用度的影响

The influence of food on bioavailability of ciprofloxacin

本文以9名健康志愿者为试验对象,在空腹和进食条件下分别交叉口服环丙沙星片剂,采用二阶导数分光光度法测定尿药浓度。结果表明:进食对环丙沙星生物利用度无明显影响。空腹和进食条件48h 尿中排药量分别为47%±8%和44%±8.4%(P>0.05)。但进食条件可延缓该药的吸收速率和缓解该药的胃肠道反应。

The ciprofloxacin tablets 500 mg were administrated to 9 healthy volunteers under the condition of fasting and after meal,in a cross-over.The urine concentration of ciprofloxacin was determined by second derivative spectrophotometry.The resultsshowed food would slight influece on the bioavailability of ciproloxacin,but could reduce the absorption rate of ciprofloxacin.The ciprofloxacin excreted within 48 h was 47±8% in fasting condition and 44±8% in after meal group(P>0.05).