摘要
本文采用高效液相色谱法测定了正常人体内卡托普利的血浆浓度和尿排泄量,经用MCPKP程序在计算机上自动拟合,结果表明,以血管外二室开放模型描述较为合适,其分布和消除半衰期分别为0.33±0.15h 和1.84±0.54h,AUC=1300±273ng/ml.h,T_(max)=0.60±0.12h,C_(max)=634.45±62.19ng/ml,0—12h 内,Cap 原形药尿排泄量为48.29±8.92%。
The pharmacokinetics of captopril were investigated in 8 voluteers after po administration of 50 mg.the data obtainedfrom HPLC were fitted with MCPKP program on computer.The results showed that the disposition of captopril was conformedto a two-compartment open model with t_(1/2)α=1.84±0.54h,t_(1/2)β=0.33±0.15h,AUC=1300±273μg/ml.h,T_(max)=0.60±0.12h,C_(max)=634.45±62.19μg/ml,Renal excretion was the main route of elimination.the unchanged captopril excretedin urine account for 48.29±8.92% of the dose during 0-12h.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1993年第2期55-56,共2页
Chinese Journal of Hospital Pharmacy
关键词
卡托普利
药代动力学
captopril
pharmacokinetics
human