雌二醇对成年大鼠肺表面活性物质分泌的影响

EFFECT OF ESTRADIOL ON SECRETION OF PULMONARY SURFACTANT IN ADULT RATS

采用离体非灌流肺模型,观察了雌二醇(E_2)对成年大鼠肺表面活性物质(PS)分泌的影响,并探讨了前列腺素(PG)在其中的作用。结果显示:E_2(10^(-6)mol/L)可使肺磷脂释放指数和肺磷脂释放量增多,分别为对照组的150.0％(P<0.05)及160.7％(P<0.01),表明E_2可促进成年大鼠PS的分泌;PG合成抑制剂消炎痛(10^(-5)mol/L)可以抑制E_2促进肺磷脂释放的效应,表明PG在E_2促进PS分泌中起介导作用。以上结果提示E_2可能参与成年动物PS分泌的调控。

The effect of estradiol(E2) on secretion of pulmonary surfactant (PS) was investigated in isolated nonperfused lung of adult male rats. E2(10-6mol / L) could enhance the lung phospholipid release. The cumulative phospholipid release and the index of phospholipid release increased from control values of 2.62 ± 0.50mg/g lung dry w and 0.37 ± 0.07 to 4.20 ± 0.76mg/g lung dry w (P<0.01) and 0.56± 0.17 ( P<0.05 ), or increased to 160.7% (P<0.01) and 150.0% (P<0.05) of the control values respectively. This enhancement could be inhibited by indomethacin (10-5mol/L). The results suggested that E2 might take part in the modulation of PS secretion in adult animals,and the effect of E2 might be mediated by prostaglandins.