运用猴免疫缺陷病毒筛选抗艾滋病中药的实验研究

Screening of Anti-SIV Drugs from Chinese Medicinal Herbs

本文研究了40余种中药或中药有效成分的抗猴免疫缺陷病毒(SIV)的活性,实验结果发现:其中5种中药有>50%的SIV抗原阳性细胞抑制率,抑制率在30～50%之间的中药有5种。实验初步结果认为,中药可以抑制猴免疫缺陷病毒,有些中药的实验结果与国内外报道对人免疫缺陷病毒的抑制作用一致。尚发现几种未见报道的对SIV有抑制作用的中药。因此,在没有P_3级实验室的条件下,采用SIV也可以较好地在普通病毒实验室内进行艾滋病的研究工作。

The inhibitory activities of more than 40 species of Chinese medicinal herbs or their single chemical components against simian immunodeficiency virus(SIV) have been studied. The study revealed that four species of the medicinal herbs and a single chemical component had more than 50% inhibition of SIV antigen expression and five other herbs' inhibitory rate of SIV antigen expression was between 30-50%. The results showed that Chinese medicinal herbs could inhibit the SIV activity.