小柴胡汤对大鼠实验性碱性返流性胃炎的作用

Effect of Xiao Chaihu Decoction on Experimental Alkaline Reflux Gastritis in Rats

小柴胡汤水煎液5g/kg、20g/kg灌胃或十二指肠给药能显著抑制大鼠胃内灌注酸化的牛磺胆酸钠(TC)和碱性上部小肠液(UIC)所造成的急性胃粘膜损伤,减少胃粘膜出血点和水肿。小柴胡汤经口给药能抑制大鼠幽门扩张和十二指肠液返流入胃4周及8周后所造成的慢性胃炎的发生率,同时降低胃内胆酸含量;经十二指肠给药,能显著抑制胃液、胃酸分泌和胃蛋白酶的活性。结果提示,小柴胡汤有较好的抗胃炎作用,其作用同降低胃内胆酸含量、抑制胃酸分泌和胃蛋白酶的活性等机制有关。

The effects of Xiao Chaihu Decoction (XCHD) on alkaline reflux gastritis and gastric secretionin rats was observed. Results: (1) 5g/kg, 20g/kg of XCHD might markedly inhibit the gastriclesion induced by gastric feeding of sodiurn taurocholate; (2) 5g/kg, 20g/kg of XCHD mightsighficantly prevent the gastric lesion induced by gastric feeding of intestinal juice; (3) On chronicreflux gastritis model induced by spring-expanded pylorus after 4 or 8 weeks, 4g/kg-20g/kg ofXCHD might lower the incidence of gastritis, and reduce the intragastric bile acid; (4) 5g/kg and20g/kg of XCHD might significantly inhibit the secretion of gastric juice and acid as well as theactivity of pepsin. The results suggested that XCHD had anti-reflux gastritis effect.