肝风内动证三亚型的病理生理学基础研究

Study on Pathophysiological Basis of 3 Subtypes in Ganfeng Neidong Syndrome

本研究首次对肝风内动证三类亚型(肝阳化风、血虚生风、阴虚风动)进行不同层次多指标实验研究,发现肝阳化风证有:脑供血障碍和脑组织损伤表现;机体处于应激状态;调节血管平滑肌舒缩功能活性物质含量显著变化。血虚生风、阴虚风动证各类指标测定值相近,异常程度较轻。

The multiple parameters of 3 Subtypes: Ganyang Huafeng Syndrome GYHFS), XuexuShengfeng Syndrome and Yinxu Fengdong Syndrome of Ganfeng NeidongSyndrome were determined for the 1st time. It was found that there were several characteris-tics in GYHFS. (1) Disturbance of the cerebral blood flow and the damage of brain tissue wasmanifested by the abnormality of the bulbar conjunctival microcirculation, carotid Doppler ultra-sonic determination and brainstem auditory and visual pathway, high blood viscosity, dysmnesia,free radical and lipid peroxidation injury and the changes of Zn, Cu, K and Mg after brain damage.(2) Stress status were expressed by the high plasma levels of cortisol, norepinephrine and epine-phrine, decreased serum triiodothyronine level and hyperfunction of sympathetic nerve. (3)Themarked changes of the regulating substance of the vessel smooth muscle function including theincreased plasma levels of TXB_2, TXB_2/6-k-PGF_1α, and calmodulin, as well as decreased SP, ANP,CGRP. Other 2 subtypes had about the same changes of these parameters, but of milder disorders.