血尿唾液酸、尿NAG与肾炎湿热证的关系

Study on Relationship between Dampness-Heat Syndrome of Glomerulonephritis and Sialic Acid and NAG

通过87例慢性肾炎的临床对比观察,发现肾炎湿热证组尿唾液酸(SA)、尿N-乙酰-β-氨基葡萄糖苷酶(NAG)含量明显高于非湿热证组(P<0.05～0.01)。16例慢性肾炎急性发作型均表现有湿热,其血、尿SA,尿NAG水平均显著高于非湿热证组(P<0.001),且尿SA与尿NAG里显著性正相关(r=0.751),并与尿蛋白量相平行。经单味清热利湿药黄蜀葵花治疗后,两组尿SA、NAG均呈显著性下降,尿蛋白量亦明显减少(P<0.05～0.001),说明尿SA、NAG值可作为肾炎湿热证的客观辨证指标及疗效参考指标。

Plasmic and urinary sialic acid and urinary N-acetyl-β-D-glucosaminidase (NAG) of 87 glomer- ulonephritic patients with and without Dampness-Heat Syndrome were measured, and the influence of clearing up Dampness-Heat therapy on above-mentioned parameters was investigated. The results showed that P_(sa), U_(sa) and U_(NAG) of Dampness-Heat Syndrome were significantly higher than those of non-Dampness-Heat Syndrome (P< 0.05-0.01). The further analysis indicated that the patients with acute onset of chronic nephritis manifested as Dampness-Heat, showed marked positive correlation between U_(sa) and U_(NAG) as well as between U_(NAG) and proteinuria respectively (r=0.75 and 0.722, P< 0.001). With the treatment of Abelmoschus manihot which could remove the Dampness-Heat, the amount of proteinuria, U_(sa) and U_(NAG) were all significantly decreased (P< 0.05- 0.001). It suggested that U_(sa) and U_(NAG) might be as diagnostic and curative parameters of Dampness-Heat of glomerulonephritis.