健脾益气方对反复呼吸道感染患儿的临床和实验研究

Effects of the Jianpi Yiqi Prescription in Treating Infantile Repetitive Respiratory Infection

应用健脾益气方治疗反复呼吸道感染患儿(复感儿)并与转移因子治疗组作对照,结果健脾组显效率74.5%,总有效率92.1%;对照组显效率8%,总有效率72%,两组比较有显著性差异(P<0.05)。治疗后两组IgG均有提高。但提高幅度健脾组>对照组(P<0.05)。实验证明:健脾益气方药物浓度5%时,体外实验对·OH清除率为76%,对O_2^-清除率为38%。在直接溶解及溶解加透析后均具有SOD活性。本文并探讨了本病脾气虚复感儿与自由基的关系。

A clinical and experimental study to evaluate effects of the Jianpi Yiqi (JPYQ, Invigorate thespleen and supplement the Qi) prescription was conducted, in contrast to 51 cases treated withtransfer factor. The results showed that there were statistically significant differences between twogroups for therapeutical effects (P< 0.003). In the experimental group, the effective rate and the total effective rate were respectively 75% and 92.1%; while in Control group, 8% and 72%. Measuringimmunoglobulin (IgG), both groups were increased, but the experimental group was higher than thatof control (P< 0.001). The inactivation in oxygen free radicals of JPYQ was determined by electronspin resonance (ESR) in vitro. When the concentration was 5%, the clearance rate of the morereactive hydroxyl radical (OII) was 78%, and superoxide radical (O2) was 38%. Whether directdissolution or dissolution combined with dialysis was performed, there was superoxide dismutase(SOD) activity. In addition, the relationship between infantile repetitive respiratory infection withSpleen Qi Deficiency and free radicals were discussed.