桂枝汤对体温双向调节作用的机理探讨——对下丘脑前列腺素E_2的影响

Mechanism of Guizhi Tang on Dual-Directional Thermoregulation —Effect on PGE Level in Hypothalamus of Rats

灌胃给予桂枝汤10g/kg,可使酵母致热大鼠的体温下降,使安痛定引起体温低下大鼠的体温升高。用放射免疫法测定下丘脑和血浆的前列腺素E_2(PGE_2)含量,在发热动物中,桂枝汤灌胃使PGE_2水平下降;在低温动物中,桂枝汤使PGE_2水平提高;灌胃给予桂枝汤对PGE_2脑室注射致热大鼠,也有快速解热作用。提示桂枝汤可能通过促进或抑制中枢发热介质PGE_2的代谢而参与对体温的双向调节。

Antipyretic action was found in febrile rats induced by yeast, and body temperature waselevated in hypothermia rats induced by aminopyrine, when 10g/kg of Guizhi Tang (GZT) wasadministered per os. The content of prostaglandin E in the hypothalamus of rats was determinedwith the radioimmunoassay. Administration of GZT in 10g/kg p. o. could both decrease the PGE_2level of hypothalamic blood in febrile rats, and increase the PGE_2 level in hypothermia rats.Antipyretic action of GZT was also displayed when microinjection of PGE_2 into the lateral ventriclewhich produced fever in rats. The evidence was provided that GZT might carry out at least part ofthe dual-directional regulating action in body temperature through the promotion or inhibition onPGE_2 synthesis, release, or metabolism in the thermoregulatory center.