胃肠癌T抗原的表达及其意义

Expression of T-Antigen end Its Significence in Gastrointestinal Carcinoma

本文应用花生凝集素(PNA)对52例人胃癌和82例结直肠癌进行了亲合组织化学研究。结果表明,胃癌T抗原阳性率是100％,结直肠癌T抗原阳性率是86.6％;正常胃粘膜的部分细胞可见阳性,正常结直肠粘膜全不表达T抗原。作者认为,T抗原对结直肠癌具有较高的特异性,而对胃癌没有特异性,只是肿瘤相关标记。胃肠癌T抗原的定位呈现3种分布形式:(1)腔膜型:沿癌性腺体的腔面呈线状分布,局限于癌细胞的腔面细胞膜及紧邻腺腔的顶部胞浆;(2)胞浆型:定位于癌细胞的部分胞浆或整个胞浆,且失去极性分布;(3)混合型:即以上两型的混合形式。癌细胞T抗原的定位分布与胃肠癌的分化程度和组织学类型有关。

T-antigen was detected through its binding to peanut agglutinin (PNA)in 52 gastric carcinomas and 82 colorectal carcinomas. Postitive reactions were seen in all gastric carcinomas and in some epithelial cells of the normal gastric mucosa. 86.6% of the colorectal carcinomas showed affinity for PNA,whereav none of the normal colorectal mu- cosa cells bound PNA. These results demonstrate that T-antigen could be specific for human colorectal carcinoma and might be of no significance in human gastric carcinoma. Three distribution patterns of T-antigen in the gastrointestinal carcinoma were identified:typeⅠ,luminal membranous;typeⅡ,intracytoplasmic and typeⅢ,mixed. Marked relation- ship had been found between the localization of T-antigen and the histologic classification as well as differentiation of the gastrointestinal carcinoma.