癌胚抗原与胃癌生物学行为免疫组织化学研究

Relationship between Carcinoembryonic Antigen and Biological Behaviour of Gastric Cancer.An Immunohistochemical Study

表文采用免疫组织化学技术对84例胃癌切除标本进行CEA染色,发现肿瘤浸润浆膜及有淋巴结转移组CEA阳性率明显高于未浸润浆膜及无淋巴结转移组。但CEA存在与肿瘤分化程度无关。按PTNM分期,Ⅲ期病人CEA阳性率(82％)明显高于Ⅰ及Ⅱ期者(44％)。本文结果提示,阳性肿瘤有扩散及转移倾向,CEA产生可能与病期有关。CEA免疫组织化学染色对于估价病人预后有较高的价值。

The expression of carcinoembryonic antigen(CEA)in gastric cancer specimens obtained from 84 patient was studied by avidin-biotin peroxidase complex(ABC)method. The percentage of positive CEA was significantly higher in patients with serosal invasion and nodal metastasis than that in patients without. However, the CEA expression in cancer had no correlation with the tumor differentiation. According to the pTNM classification, most patients of stage Ⅲ were CEA(+)(82%), and only 44% of stageⅠand Ⅱ patients was CEA(+). The result suggests that tumor with positive CEA is more agressive and the tumor may be in an advanced stage. Immunohistochemical staining of CEA in tumor tissue is of value in estimating the prognosis of gastric cancer.