强力化疗加自体骨髓移植术治疗中、晚期实体瘤9例报告

Intensive Combination Chemotherapy with Autologous Bone Marrow Transplantation in Advanced Solid Tumor.A Report of 9 Cases

本文报告用强力化疗加自体骨髓移植治疗中、晚期恶性肿瘤9例。其中骨肉瘤3例,恶性淋巴瘤3例,肾胚瘤、脑胶质细胞瘤、骨转移癌各1例。结果2例淋巴瘤、1例肾胚瘤1～2个月内完全缓解,其它5例恶性肿瘤均有效,1例脑胶质瘤无效。结果还表明自体骨髓移植治疗恶性实体瘤,4℃保存骨髓较深低温保存更为实用有效;较少量骨髓有核细胞输入也有利于强化治疗后血象的恢复,且无移植物被排斥的后顾之忧。

Nine patients with advanced malignancies (3 malignant lymphomas, 3 osteosarcoma, 1 each of Wilm' s tumor, brain tumor and bone metastasis)were treated with intensive combination chemotherapy and followed by autologous bone marrow transplantation (ABMT). Three of them achieved complete remission ,1 partial remission, 4 fair responses,l no response. The results demonstrate that ABMT is feasible in patients with advanced solid tumor and that it can shorten the duration of bone marrow aplasia following high dose of chemotherapy even by using less nucleated mar- row cells. This form of treatment warrants further application in patients with advanced malignancies.