大鼠严重烧伤后心室肌匀浆丙二醛含量与心室肌形态学改变

Observations on MDA Content and Morphological Changes in Ventricular Myocardium in Burnt Rats

观察了大鼠30%、Ⅲ度体表烧伤后1周内的心室肌匀浆丙二醛(MDA)含量变化与心室肌形态学改变。结果发现心室肌病变具有出现早、形态多样、病变重的特点,表现为一个动态过程,大致可分为三期:损伤起始期,损伤严重期和恢复期;自由基可能参与了本组实验动物的心室肌损伤。

The purpose of the experiment was to investigate the changes of malondialdehyde (MDA) level and morphological changes in ventricular myoeardium in burnt rats. The results showed that the pathological changes of ventricular myocardium were characterized by its being presented early, severity and multiple patterns; the pathological changes underwent a dynamic course, which could be roughly divided into three phases: the early phase, aggravative phaes and recovery phase of the injury; oxygen-derived free radicies might be a participant in injuring ventricular myocardium according to the experiment.