垂体催乳素微腺瘤经蝶手术与溴隐亭治疗后CT及内分泌变化

Changes of CT scan and prolactin of prolactin secreting microadenomas after treatment

本文报告78例垂体催乳素微腺瘤治疗后 CT 及内分泌变化。其中男2例,女76例,平均年龄30.6岁,治疗前催乳素均高于正常,CT 扫描均有垂体内低密度病灶(<10mm)。32例经蝶手术,术后25例催乳素恢复正常;CT 复查肿瘤消失28例,缩小4例;46例服溴隐亭治疗,19例催乳素恢复正常,CT 复查肿瘤消失1例,缩小3例,不变33例,增大9例。对垂体催乳素微腺瘤的疗效问题进行讨论。

The change of CT scan and prolactin(PRL)deter-mination were studied in 78 PRL microadenomas.There were 76 females and 2 malel.Mean age was30.6 years.PRL was higher than normal level in allpatients before treatment.All tumors were lower den-sity in CT scan and their diameter were less than10mm.32 PRL microadenomas were removedtranssphenoidally by microsurgery.The follow-up pe-riod was 5 months～3 years.PRL level restored tonormal in 25 cases(78%).CT scan showed tumor dis-appeared in 28 cases,shrinked in 4 cases.46 patientswere treated by oral bromorcriptine for 3～6 months.PRL level restored normal in 19 cases(41%).CT scanshowed tumor disappeared in one case,shrinked in 3cases,unchanged in 33 cases and enlarged in 9 cases.The therapeutic efficiency of PRL microadenoma is dis-cussed.