额、颞叶癫痫的神经病理与中枢生长抑素含量变化

Neuropathology and alteration of central somatostation concentration in intractable epilepsy

本文通过对16例难治性额、颞叶癫痫患者手术切除标本的病理结果与病灶组织中中枢生长抑素(SS)含量变化的对比分析发现本组癫痫患者是由外伤后疤痕、海马角硬化、肿瘤和血管异常四类改变所致。不同的病因痫灶中 SS 含量均明显增高。额、颞叶痫灶组织中 SS 含时增高程度相似。四个病理组患者痫灶组织中 SS 含量比较有区别,证实了脑组织 SS 含量增高出现在病理到改变明显的区域。

Sixteen cases of intractable epilepry were treatedby surgery.The removed epileptic foci were investigat-ed pathologically,and alteration of central Somatosta-tion(SS)concentration were detected also.The patho-logical changes were scar after head injury,Ammon'shorn sclerosis,tumors and vascular changes.The cen-tral SS concentration in all epileptic foci were in-creased.The increased levels of central SS concentra-tion in epileptic foci of frontal lobe was similar to theepileptic foci of temporal lobe.But was statisticallysignificant in different pathological changes.The fol-lowing values were obtained(mean±s):106.39±12.41pg/mg in epileptic foci of scar after head injury,79.14±20.97pg/mg in Ammon's horn sclerosis,59.5±15.21pg/mg in tumors,57.3±15.2pg/mg in vascularchanges.According to the special distribution and ef-fect of physiology of SS concentration in central nerve system we considered that increased levels of SS con-centration in epileptic foci may related to the site of le-sions,course and frequency of seizure.