普通型脆性部位与鼻咽癌发生关系的研究

RELATIONSHIPS BETWEEN THE COMMON FRAGILE SITES AND THE OCCURRENCE OF NASOPHARYNGEAL CARCINOMA

采用GTG显带及染色体原位切口移位技术,分别对20例鼻咽癌患者及健康对照者所检出的普通型脆性部位(c-fra)和罕见型脆性部位(r-fra)进行了分析。结果表明:病例组c-fra为13.4%,对照组为4.10%(P<0.001),而r-fra病例组为1.20%。对照组为0.7%(P>0.05).同时,所定位的c-fra与癌断裂点、癌基因位点三者均位于G带的浅带区,特别是c-fra lp32位于DNàse-Ⅰ敏感区,对探讨鼻咽癌发生机理有一定参考价值。

We have analyzed the common fragile sites (c-fra) and rare fragile sites (r-fra) by G-banding techniques in 20 cases of nasopharyngeal carcinoma (NPC) and in 20 cases of healthy persons. The results showed a highly significant difference (P<0. 001) in the c-fra rates between the NPC (13.40%) and the controls (4.01%), but no significant difference (P>0.05) was noted in the r-fra rates between the NPC (1.20%)and the controls (0.70%); the c-fra sites, cancer breakpoints and oncogene sites were located by G-light bands, and the c-fra lp32(2.20%)were located at the DNase-1 sensitive regions.