摘要
机体烧伤后,各种生理功能(包括免疫功能)受到严重干扰。我们对25例Ⅲ度烧伤面积为11.48±5.80%患者的红细胞免疫功能,血清纤维连接蛋白(Fn)及补体成份C_3、C_4进行了检测。结果显示:烧伤患者及正常对照组红细胞C_3b花环分别为14.28±4.58%,17.33±4.07%(P<0.01);红细胞免疫复合物(IC)花环分别为4.68±1.77%、4.94±1.26%(P>0.05);血清Fn分别为234.28±98.05mg/L、312.50±70.99mg/L(P<50.01);血清c_3分别为2014.24±438.40mg/L、1960.00±613.30mg/L(P<0.05);c_4分别为601.11±84.71mg/L、598.24±111.09mg/L(P>0.05),即未烧伤病人IC花环、C_3、C_4改变不明显,而C_3b花环百分率和血清Fn浓度显著低于正常人,这与患者抗感染能力低下有一定关系。
The immune function and many other physiological functions are severely interfered with in patients following burn injury. This paper reports the results of determinations of the red cell immune function, the serum concentration of fibronectin (Fn), C3 and C4 in patents with burn injury, whose third—degree burns covered 11.48±5.80%. The rosette rate of red cell C3b receptors in the patients and normal individuals werel4.28±4.58%and 17.33±4.07% (P<0.001),and that of red cell immune complex (IC)4.68±1.77%and 4.94±1.26(P>0.05),the serum Fn level 234.28±98.05mg/Land 312.50±70.99mg/L(P<0.01),C3 2014.24±438.40mg/L and 1960.00±613.30mg/L(P>0.05). C4 601.11±84.71mg/L and 598.24+111.09mg/L(P2>0.05), respectively. In the patients, the rosette rate of red cell 1C and the serum concentration of C3 and C4 did not change remarkably, but the rosette rate of red cell C3b receptors and the serum fibronectin level were reduced markedly in comparison with normal controls. The decrease of the last two was related to the failure of anti-infectious capacity of patients with burn injury.
