摘要
正常皮肤、增殖性疤痕和疤痕疙瘩成纤维细胞的体外培养研究,发现三者具有相同的密度依赖性抑制,形态学观察无明显差异,但后二者细胞排列紊乱,有明显的交叉重叠,不同于前者的平行极性排列。三者的生长曲线、DNA合成和分裂指数无明显差异。
The fibroblasts from normal skin, hypertrophic scar and keloid were cuhured in vitro and their growth property was compared. The results showed that there was similar density—dependent inhibition in these three strains, and there were no morphological differences among them. But, in normal skin, fibroblasts were parallelly arranged, showing 'fingerprint' and marked polarization, while that in hypertrophic scar and keloid presented crisscross and overlapping with less polarization. All of three strains had same growth kinetics, i. e. the cell growth curve, DNA synthesis and mitosis index were similar during their logarithmic phase.
