烧伤休克因素对小白鼠烧伤创面脓毒症预后的影响

The influence of burn shock on the prognosis of burn wound sepsis in mice

我们是在小白鼠烧伤创面脓毒症模型中观察休克因素对烧伤创面脓毒症预后的影响。小白鼠造成１３％体表面积Ⅲ度烧伤，即刻在焦痂下接种１×１０＾３／ｍｌ绿脓杆菌悬液０．２ｍｌ或５×１０＾３／ｍｌ肺炎杆菌悬液０．２ｍｌ。在小白鼠绿脓杆菌烧伤创面脓毒症中，复苏组（ｎ＝５３）动物７天生存率为４９％，而不复苏组（ｎ＝２４）为１７％（Ｐ〈０．０１）。复苏组死亡动物（ｎ＝２７）平均生存时间为４．２±１．７天，不复苏组…

The influence of burn shock on the prognosis of burn wound sepsis was investigated in mice. Mice with full-thickness burn of 13% TBSA was injected subcutaneously under the burned area immediately after burning with 0. 2ml P. aeruginosa (1×10~3CFU/ml) or 0.2ml K. pneumoniae (5×10~3CFU/ml). The survival rate in P. aeruginosa burn wound sepsis was 49% in resuscitation group (n=53) on 7 postburn day and 17% in non—resuscitation group (n=24) (P<0.01). The mean survival time in dead mice of resuscitation group (n=27)was 4.2±1.7 days and 2.5±0.6 days in that of non-resuscitatisn group(n=20) (p<0.01). The survival rate in K. pneumononiae burn wound sepsis was 69% in resusciatation group (n=26) on 7 postburn day and 15% in non—resuscitation group (n=13) (P<0.01). The mean survival time in dead mice of resuscitation group (n=8)±1.35 days and 2.1±0.3 days in that of non-resuscitation group(n=11)(p<0.01). These results indicated that burn shock might increase the mortality of burn wound sepsis and resuscitation could improve the prognosis of burn wound sepsis.