31例系统性红斑狼疮的临床和实验诊断研究及检查结果分析

CLINICAL MANIFESTATION AND LABORATORY DIAGNOSIS OF 31 CASES OF SLE

对31例系统性红斑狼疮病例的包括发热等26项的临床表现及包括ANA等13项实验检查指标(急性期和缓解期)进行了分析研究,结果表明,在疾病急性期,其ANA(+)高滴度(31:160)几乎占1/2,缓解期即下降到近1/10;6例狼疮带(+)患者中1/2为低补体血症,并有5/6表现为狼疮性肾炎;与一般资料相反,没有发现抗SmAb(+)者雷诺氏现象也(+);抗SSA Ab(+)中有口眼干燥者只占25％,大大低于某些文献报道的80％;并报道了本Ab与光过敏、皮肤红斑等临床表现的关系。同时,本文的病理活检证实了:SLE患者通常是Ⅲ型变态反应,又可以是同时兼有Ⅱ型和Ⅳ型“复合型”变态反应性疾病群体。

In 31 cases of SLE from 1985～1989, 26 items of clinic manifestations and 13 laboratory diagnosis were analysed and studied. Results showed: ANA titers of 1/2 of the patients were very high 1: 160 during acute phase, which decreased to 1: 10 when progressing into relieving phase. Of the 6 Lupus Band patients, 3 were hypocomplementemia and 5/6 manifested Lupus Nephritis. In contrast to that reported previously, Sm Ab(+) patients were also Raynaud's phenomenon (+). Of the SS Ab (+) patients, only 25％ manifested Sicca Syndrome, much less than 80％ in previous reports. It was reported the first time in China the relationship betwem SSA Ab and photosensitivity and skin erythema. Biopsy also proved that SLE patients could be Ⅲ Allergy Patients, or combined with Ⅱ and Ⅳ Allergy.