长春降压液对高血压患者心功能及血浆去甲肾上腺素的影响

THE EFFECT OF LONGEVITY-ANTIHYPERTENSIVE-MIXTURE ON CARDIAC FUNCTION AND PLASMA NE IN HYPERTENSIVE PATIENTS

给30例中、老年肾虚型高血压患者和11例正常血压的健康人应用了滋阴补肾药一长生降压液,观察其对某些心功能及血浆去甲肾上腺素(NE)的影响,结果表明:高血压患者的外周阻力(TPR)明显高于血压正常者;而主动脉顺应性(AC)则明显低于血压正常者。该药可明显降低肾阴虚型高血压患者的TPR和血浆NE水平。非肾阴虚型高血压患者仅有上述变化趋势。结果提示:改善交感神经紧张性调节、降低血浆NE水平从而影响外周阻力,可能是长生降压液降低血压的作用环节之一。在高血压病的中医治疗中重视辩证分型对提高疗效是极为有益的。

The effect of Longevity-Antihypertensive-Mixture (LAM) on the cardiac function and plasma NE in 30 middle-aged hypertensive patients with kidney deficiency pattern was studied. The results were as following:①the total peripheral resistanse (TPR) was significanly higher and aorta compliance (AC) was markedly lower in hypertensive patients compared with normotensive subjects; ②after two months medication, there was significant reduction of TPR and AC compared with the baseline figures in hypertensive patient with kidney Yin-deficiency. While other groups only had a tendency of reduction; ③the level of plasma NE was markedly lowered in hypertensive patients with kidney Yin-deficiency. The results indicated that LAM had marked lowering effect on TPR and plasma NE in hypertensive patients with kidney Yin-deficiency and supported the therapeutic principle of traditional Chinese medicine.