复方肝宁保肝及提高免疫功能的作用

EFFECT OF FUFANG GANNING ON PROTECTING LIVER AND ENHANCING IMMUNITY

复方肝宁是由黄芪、丹参、郁金、黄精等8味中药组成的经验方制成口服液,它对四氯化碳引起的小鼠,大鼠急性肝损伤有明显的保护作用,能降低转氨酶(ALT),使磺溴酞钠(BSP)潴留减少,病理组织学也相应改善,对硫代乙酰胺和 D-半乳糖胺引起急性肝损也有保护作用,并对α-萘异硫氰酸酯引起的小鼠、大鼠实验性黄疸肝损模型有降酶和降低血清胆红素作用。复方肝宁对四氯化碳诱发实验性肝硬化模型有降酶和使肝细胞变性、坏死及肝硬化明显减轻,能提高正常小鼠对碳粒的廓清指数和血清溶血素,增强免疫功能。

Fufang Ganning(FGN)is an oral liquid,consisting of 8 kinds of chinese herbs including Radix Astragali,Radix Salviae Multiorrhizae,Radix Curcumae,Rhizoma Polygonati,etc.It was found to be effective in protecting against experimental acute hepatic damage caused by CC14,TAA and D-Glan in mice,FGN could reduce ALT and retention of BSP,and histopathological chan- ges revealed that the hepatic injury induced by CC14 in animals received FGN was much less severe than those of the control ones.It could also lower ALT and serum bilirubin in mouse and rat models with hepatic injury caused by α- isothioeyanate.On the other hand,in the animal models with cirrhosis induced by CC14,FGN could not only cut down ALT but also lessen the degeneration and necrosis of hepatic cells and cirrhotic changes.Meanwhile,FGN could significantly increase the clearance index of carbon particles(phagocytic func- tion)and serum hemolysin in normal mice.It is concluded that FGN has the effects of protecting liver from damage and enhancing the immune function.