闹羊花根对狗肝、肾亚急性毒性的研究

A Subacute Toxicological Study on Radix Rhododentri Mollis

将家犬分为4组,每组4只,雌雄各半。以闹羊花根0.170、0.345、1.420g/kg剂量分3组饲喂家犬3个月,另一组为对照组。实验发现闹羊花根可致家犬肝灶状坏死,肝细胞水肿、气球样变性、脂肪变性;肾小球通透性增高、肾小管上皮细胞水肿、气球样变性。生化测定:GPT及BUN值有增高趋势,与对照组比较,给药45天后,高剂量组GPT有极显著性差异,BUN有显著性差异。尿常规:蛋白定性、上皮细胞、白细胞、红细胞均呈阳性。认为闹羊花较长时问应用时,可致肝、肾功能结构损害,及时停药、治疗有一定可复性。

Sixteen dogs were allocated to 4 groups in equal number and were fed with Rad ix Rhod od end ri Mollis 0.170, 0.345 and 1.420 g/kg for three months respectively, with one group as control. The results showed that Rad ix Rhod od end ri Mollis can cause focal necrosis, edema, ballooning degeneration and fatty degeneration of liver cells. It can also increase the permeability of glomerulus, and cause edema and even ballooning degeneration of renal tubular epithelial cells. Biochemical analysis showed that GPT and BUN apparently increased. Urine analysis showed that qualitative examination of protein, epithelial cells, white and red blood cells were all positive. It is considered that long-term administration of Rad ix Rhod od end ri Mollis can cause functional and structural damage of liver and kidney, and timely suspension of the drug and treatment may render the damage.