亚硒酸钠对亚硝基胍诱发大鼠腺胃胃癌的影响

Influence of Sodium Selenite on the Carcinogenesis of Glandular Stomach Induced by N-Methyl-N'-nitro-N-nitrosoguanidine in Rats

本文报告亚硒酸钠对N-甲基-N’-硝基-N-亚硝基胍(MNNG)诱发大鼠腺胃胃癌的影响。结果表明大鼠饮水每日添加10mg/kg的亚硒酸钠可以抑制MNNG诱发腺胃胃癌、异型增生及前胃病变的发生,并促进癌周纤维组织增生及包裹形成。在大鼠MNNG诱癌实验中,硒作为化学预防剂的每日添加量应低于每只20mg/kg,而饮水浓度不宜超过4mg/L。

We report the influence of sodium selenite on the carcinogenesis of glandularstomach induced by N-MethyI-N'-nitro-N-nitrosoguanidine (MNNG) in rats. Theresults suggest that 10mg/L sodium selenite supplemented in drinking water of rateach day can inhibit the dysplasia and carcinoma of the glandular stomach, as wellas the forestomach lesions induced by MNNG, and also can promote the fibrousproliferation around the carcinoma nests. In the experiment of carcinogenesis indu-ced by MNNG in rats, the quantity of adding selenium as a chemopreventive agentshould be less than 20mg/L each rat per day and the concentrition of drinking watershould be lower than 4mg/L. The effect of selenium inhibiting carcinoma is notmainly resulted from maintaining GSH-Px activity at higher level.