40例贲门癌切除标本切缘残留癌的DNA倍体与患者预后关系探讨

Study of Relationship between DNA Ploidy and Patient's Prognosis in Residual Tumor of Resected Margins (RTRM) for Cardiac Cancer

为探讨贲门残癌细胞的DNA倍体类型与患者预后的关系,对40例残癌细胞的DNA倍体进行了流式细胞分析。结果显示,属2C者16例,占40％;AN24例,占60％。2C患者的3年和5年生存率显著高于AN患者。这提示DNA倍体是判断残癌患者预后的一个生物学指标。本文还对残癌及其相应的主体癌细胞的DNA倍体类型进行了比较。

In order to search for the relationship between cellular DNA ploid patterns ofRTRM and the patients' prognosis, 40 cases of RTRM have been analyzed by flowcytometry (FCM) in an attempt to measure DNA ploid patterns. The results showedthat 40%(16/40) are diploid pattern (2C) and 60%(24/40) are aneuploid (AN) patte-rn. Data of the follow-up indicated that the 3, 5-year-survival rate in patients with2C are significantely higher than that in patients with AN. It suggests that DNAploid pattern is a significant prognostic indicator of patients with RTRM afteroperation. Comparison between DNA ploid patterns of RTRM and those of thecorresponding primary tumors was also performed.