血清Ⅲ型前胶原、透明质酸测定诊断肝纤化的临床评价

Clinical evaluation of determination of serum procollagen and hyaluronic acid in the diagnosis of hepatic fibrosis

本文测定167例各种慢性肝病患者血清Ⅲ型前胶原(PCⅢ)、透明质酸(HA)与常规肝功能试验。结果:慢活肝和肝硬化各组血清PCⅢ和HA显著升高,在代偿性肝硬化组中PCⅢ的诊断敏感性显著高于HA,而白蛋白降低、A/G倒置和Y球蛋白升高的敏感性均低于30％。因此诊断肝纤维化和早期肝硬化,仅测常规肝功能试验可造成多数患者漏诊,测定血清PCⅢ和HA有(?)诊断价值。

The serum procollagen type Ⅲ (PC Ⅲ), hyaluronic acid (HA) and routine liver function tests of 167 pa- tients with varied chronic liver diseases were determined in this report. The serum PC Ⅲ and HA levels of the patients with chronic active hepatitis and hepatic Cirrhosis were significantly higher than that of the normal control group. The diagnostic sensitivity of serum PC Ⅲ was significantly higher in the patients with com- pensatory hepatic cirrhosis than that of HA. However, the sensitivity of any one of serum albumin decreas- ing, inversion of A/G and r globulin increasing was less than 30% in the patients with compensatory hepatic cirrhosis. Therefore the diagnoses may be missed in the majority of these patients if only routine liver function tests would be determined. It suggests that the determination of serum PC Ⅲ and HA are significant clinical valuable in the diagnosis of hepatic fibrosis