乳腺肿瘤患者外周血淋巴细胞的姐妹染色单体交换和染色体畸变

Observations of SCE and Chromosomal Aberration in Peripheral Blood Lymphocytes from Breast Tumor Patients

本实验观察了20例乳腺癌患者、19例乳腺纤维腺瘤患者及17例正常人的外周血淋巴细胞的姐妹染色单体交换(SCE)率及染色体畸变率,结果发现乳腺癌组的SCE率及染色体畸变率均比乳腺纤维腺瘤组和正常对照组显著增高(P<0.01),而后两组之间则无统计学差异(P>0.05)。经丝裂霉素C(MMC)诱导后的染色体畸变率在三组间也存在这种区别。作者认为:乳腺癌患者具有对癌肿的遗传易感性;观察淋巴细胞的SCE率及杂色体畸变率对于乳腺肿块的鉴别诊断以及乳腺癌的预防具有临床应用价值。

The frequencies of SCE and chromosomal aberration in peripheral blood lympho-cytes from 20 breast cancer patients, 19 breast fibroadenoma patients and 17 healthycontrol individuals were studied. The frequencies of SCE and chromosomal aberra-tion in breast cancer patients was significantly higher than those in patients withfibroadenoma and in normal control (P<0.01). There was no statistical differencebetween the last two group (P>0.05). Addition of mitomycin C (0.1μg/ml) gavesimilar result. A nonrandom break on chromosome 1 was found in cancer patients.The results showed that breast cancer patients had somewhat genetic instability andwere predisposed to cancer.