Crohn病的临床及预后观察

CLINICAL FEATURES AND LONG-TERM FOLLOW-UP STUDIESIN CROHN'S DISEASE

本文报告我院1978～1991年经病理证实Crohn病20例，腹痛、腹泻、便血及肠梗阻症状较常见。并发症有肠穿孔5例，下消化道出血2例，肠梗阻2例。X线和内镜检查为诊断本病的主要手段。2例经SASP、强的松和肠外高营养治疗，病情好转后死于肠穿孔，18例手术治疗，13例随访1～13年（平均7年），12例存活，平均7(1/2)年，复发3例。对本病诊断作了简要讨论。

ABSTRACT Twenty cases with confirmed diagnosis of Crohn's disease admitted to the Southwestern Hospital from 1978 to 1991 were studied. Abdominal pain, symptoms of intestinal obstruction, lower intestinal hemorrhage and diarrhea were highly frequent in this series. Endoscopic examination revealed abnormalities in all of 5 patients. Two patients treated with. SASP, cortisone and TPN with definite improvement, but later on died of intestinal perforation. Eighteen patients required surgical intervention for intestinal obstruction, perforation and massive intestinal hemorrhage. Good to excellent effects were obtained in 12 of 18 surgically treated patients followed up for 1-13 years (mean' 7 years). Relapse was found in 3 patients, 2 of whom had treated again medically with good effect. The diagnosis of this disease was briefly discussed.