摘要
本文综述血管紧张素转换酶抑制剂的主要药理作用及临床应用近况。血管紧张素转换酶抑制剂对高血压及充血性心力衰竭的治疗已取得显著疗效,近年资料表明有保护缺血心肌的作用,可望降低心肌梗塞病人的死亡率。在糖尿病、肺动脉高压、原发性醛固酮增多症、类风湿性关节炎、Graves病、系统性硬化症及肾移植等的治疗亦获得一定临床经验。其不良反应发生低,易耐受,应用前景十分广阔。
The paper summarized the primary pharmacological effects and the recent developments of angiotensinconverting-enzyme inhibition(ACEI) in clinical use. ACEI has had a significant impact on the treatments of hypertensi on and congestive heartfailure. Recent data indicate that ACEI has also been shown being to protect for ischemic myocardium and therefore ACEI is expected to lower the mortality of patients with myocardial infarction. In addition, some clinical experiences with ACEI have been gained in diabetes mellitns, pulmonary hypertension, primary aldosteronism, rheumatoid arthritis. Graves'disease, systemic sclerosis, kidney transplantation, et al. Adverse effects with ACEI occur low and are easy borne. The future of ACEI in clinical use is extremely wide.
