新生鼠垂体移植抗衰老作用的实验研究

Studies of the Effect on the Anti-Ageing Process in Rats with Neonatal Pituitary Transplanting

为探讨垂体移植有无抗衰老作用,我们在老龄SD大鼠第Ⅲ脑室内移植新生鼠垂体。结果发现,移植组老龄鼠体重降低速度减慢,体温趋于相对恒定,运动平衡能力改善,雌鼠性功能衰退进程延缓,平均及最大活存期明显延长,萎缩的性腺有一定程度的代偿。提示新生鼠垂体移植于老年宿主后似有一定的抗衰老作用。

In order to exploer whether pituitary transplantation has some anti-ageing action, We implanted a neonatalpituitary tissue of rats into the third venticle of aged Sprague-Dawley rats. The results showed that compareingwith the control group of old rats, the rate of body weights loss of implanted aged rats was discreased, the bodytemperature was tended constant, the ability to maintain balance on a narrow wooden bridge was immproved,failure of reproductive function in female group was delayed, the average lifespan and maximum lifespan wereprolonged significantly, and the atrophic ovaries and testes have got a recovery to a certain degree. All these re-sults suggest that the neonatal pituitary transplantation seems to have some anti-ageing action on old rats.