甲氧西林耐药金黄色葡萄球菌耐药性的研究

Study on Resistance to Antimicrobial Agents of MRSA

甲氧西林耐药金葡菌(MRSA)感染发生率有逐年增加趋势。为了解MRSA耐药特点及合理选用抗菌药物,本文测定了18种抗菌药物对临床分离金黄色葡萄球菌(SA)的最低抑菌浓度(MIC)、受试菌的β-内酰胺酶及凝固酶分型。结果表明MRSA占临床分离SA的50.7％,其中产β-内酰胺酶菌株占85.1％,MRSA凝固酶均为Ⅱ型。MRSA对多数β-内酰胺类及某些氨基甙类抗生素呈多重耐药性。万古霉素、阿贝卡星对MRSA显示最强的抗菌活性;米诺霉素、阿米卡星、妥磺沙星、亚胺培南亦显示较强抗菌活性,提示上述抗菌药物可用于MRSA所致严重感染。

The morbidity of the infections caused hy MRSA was increased with years, in order to know the resistance to antimicrobial agents of MRSA, the minimum inhibitory concentrations (MICs) of antimicrobial agents against S. aureus isolated from patients and tested by B-lactamase and coagulase were measured. The results showed that MRSA was account for 50.7％ of the strains tested, the incidence of MRSA producing B-lactamase were 85.1％, the coagulase of MRSA Was type 1. MRSA showed multiple-resistance of most of B-lactam antibiotics and some aminoglycosides. Vancomycin and arbikacin had the highest activity against MRSA, the other drugs were in the follwing order: minocycline, amikacin, tosulfloxacin, imipenem and cloxacillin. It suggested that serious infections caused by MRSA may be cured by using the vancomycin, arbikacin or other drugs mentioned above.