胃癌及大肠癌雌激素受体水平与其病理的关系

A Study on the Relationship Between the Estrogen Receptor (ER) Level and the Clinical-Pathological Changes in Varions Type of Gastrointestinal Tmors

本研究应用放射配基法检测了胃癌及大肠癌各35例癌组织中的雌激素受体(ED)水平,并分析了非雌激素靶器官的胃癌及大肠癌中ER的阳性率与其某些临床病理变化之间的关系。结果:70例胃癌及大肠癌中21例呈ER阳性,阳性率为30％,其中胃癌的ER阳性率为25.7％,大肠癌34.3％。胃癌ER多发生于大体标本为BorrmannⅢ型,组织学上则以低分化腺癌多见;大肠癌ER阳性在DukeC级有增多的趋势,组织学上则表现为细胞分化程度越高,ER阳性率越高。本研究表明:部分胃癌及大肠癌中出现的ER提高这些肿瘤的发生及发展过程中可能与性激素有关,因此对某些晚期或因复发而失去手术根治机会的胃癌及大肠癌,采取内分泌治疗作为一种新型的辅助治疗手段具有广阔的前景。

Estrogen receptor in 70 primary gastrointestinal cancer were determined using Radioligand Binding Assay(RBA) method and following results were obtained: Although ER was nagative in normal gastrointestinal mucosa, of 70 cancers studied, 21 exhibited positive estrogen receptors. Gastric cancer 9/35 (25.7); colorectal cancer 12/35(34.3). In all cancers with positive receptors the binding activity ranged from 10.99—57.1 fmol/mg. P for gastric cancer and from 10.37—33.15 fmol/mg. P for colorectal cancer. Th ese value were lower than that of breast cancer. Estrogen receptors were frequently detectable in poorly differentiated histologic type of gastric cancer, while they were more frequently detectable in welldifferentiated histologic type of colorectal cancer. ER-positive cases were characterized grossly as Borrmann type Ⅳ in gastric cancer and were most frequently associated with Dukes' Classification of C in colorectal cancer. The presence of ER in some gastrointestinal cancer indicates the possibility that sex hormone facters are involved in these tumors which may be endocrine-dependent.