老年人粒细胞缺乏症3例报告并文献复习

Agranulocytosis in the Elderly: Report of 3 Cases and Review of Literatures about Treatment with GM-CSF

报告3例老年人药物所致的粒细胞缺乏症患者应用重组人粒细胞—巨噬细胞集落刺激因子(rhGM-CSF)治疗情况、并就其疗效、剂量、副作用及注意事项等问题结合文献进行了讨论。

Three cases of acute agranulocytosis in the elderly caused by drugs were reported. We primarily treated these patients with GM-CSF ie our hospital and all were cured. The rise in peripheral blood WBC count and neutrophils plus band forms were seen within 3—14 days after the infusion of GM-CSF was started. The elevation in WBC count was dose dependent, at doses of GM-CSF 120μg/per square meter of body surface per day or higher the WBC count continued to increase until the end of the course. They recovered completely within 6—15 days. The authors recommended that 120—180μg/per square meter of body surface per day, or 3.5—5μg/per kilogram body weight per day may be the suitable doses of GM-CSF, GM-GSF was administered by continuous Ⅳ infusion through 4—6 hours disulved in 5％ glucose solution 500ml for 5—7 days, The side effects of GM-CSF were also discussed.