血栓性血小板减少性紫癜病人血浆对血小板作用的异质性

HETEROGENEIC EFFECT OF THROMBOTIC THROMBOCYTOPENIC PURPURA PLASMA ON PLATELET AGGREGATION

观察11例血栓性血小板减少性紫癜(TTP)急性期病人血浆,和从1例急性期TTP患者血浆中提纯的血小板聚集蛋白对12名健康志愿者,5例恢复期TTP病人血小板以及兔、大鼠和猴血小板的致聚作用,发现在程度和性质上均存在明显的个体差异。在聚集活性较强的6组TTP血浆-人血小板中,进一步观察几种抑制物对TTP血浆诱发血小板聚集的影响,结果在阐明本病发病机理的多元论和临床治疗的个体化方面有实际的意义。

Platelet aggregation response of washed platelets from 12 healthy donors and 5 patients with thrombotio thrombooytopenio purpura (TTP) after recovery and from rabbits, rats and monkeys to 59 000u platelet-aggregating protein and plasmas from 11 TTP patients during their acute episodes was studied. The platelets from various donors and animals reacted variably to TTP plasma from different patients and platelet-aggregating protein. All of the platelets from TTP patients after recovery were aggregated by their own plasma obtained during the acute phases of the disease. Heterogeneio reactions of the' donor's platelets could not be associated with age, sex, race or ABO blood types. It was found that certain platelet inhibitors, IgG or Platelet-aggregating protein inhibitor from normal plasma affected variably TTP plasma-induced platelet aggregation. Heterogeneio properties of platelet-aggregating/agglutinating substances in TTP plasma may be of diverse etiology. Treatment of TTP should be individualized according to different platelet-aggregating/agglutinating substances in their plasma.