摘要
用Fos抗体免疫组织化学法在γ-羟丁酸诱发的大鼠失神性癫痫持续发作模型上,对丘脑Fos癌蛋白表达的分布进行了研究。失神性癫痫发作后30min,双侧丘脑室旁核内可见到少量Fos免疫阳性细胞核;1h时,Fos的大量双侧标记分布于外侧缰核、室旁核、菱形核和丘脑板内核群。提示外侧缰核及丘脑中线和板内核群极可能涉及失神性癫痫发作的病理生理机制。
Using the model of gamma-hydroxybutyrate (GHB)-induced generalized absence epilepsy, the present work investigated the distribution of Fos oncoprotein expression in the rat thalamus with Fos antibody immunohistochemistry. 30 minutes following absence-like seizures, some Fos-immunoreactive cell nuclei were found in bilateral thalamic paraventricular nuclei (PV). Another 30 minutes later, a massive bilateral induction of Fos was observed in lateral habenular nucleus(LHb), PV, rhomboid thalamic nucleus, and intralaminar nuclei of the thalamus. These results suggest that the LHb and the midline and intralaminar thalamic nuclei may very likely be involved in the pathophysiology of absence seizures.
出处
《解剖学报》
CAS
CSCD
北大核心
1993年第1期30-33,T004,共5页
Acta Anatomica Sinica
基金
国家自然科学青年基金资助
关键词
癫痫
羟丁酸
丘脑
癌基因
Absence epilepsy
Gamma-hydroxybutyrate
Thalamus
Oncogene
c-Fos
Immunohistochemistry
Rat
