电镜在脂肪肉瘤诊断中的意义

Significance of Electron Microscope in Diagnoses of Liposarcoma

从2183例电镜诊断病例中收集最后电镜观察明确为脂肪肉瘤的16例进行回顾性分析,重点对比光镜和电镜的观察后发现,其中分化好的脂肪肉瘤2例及多形性脂肪肉瘤3例无论光镜及电镜诊断上都不困难。粘液型脂肪肉瘤5例,如果抓住丰富的分枝状小血管及找到脂肪母细胞,光镜诊断也不困难,但对于梭形细胞的3例和圆形细胞的3例,光镜下要肯定诊断较困难,但电镜下则可见到瘤细胞内脂滴、细胞膜外的基板及找到吞饮小泡的特点,有助于脂肪肉瘤的诊断。

Liposarcomas are malingant lesions of adipose tissue.Four subtypes of liposarcomas aregenerally recognized—well differentiated,myxoid,round-cell and pleomorphic.Sixteen cases of li-pesarcomas diagnosed by EM from the files of 2183 cases in the Dept.of Pathol.Chinese PLA GeneralHospital were analysed.Among them,2 cases of well differentiated and 3 cases of pleomorphic were di-agonsed by LM and EM without difficulty.Five cases of myxoid could be diagnosed by LM depening onthe plexiform vascular networks and lipoblasts.Three cases of spindle-cell type and 3 cases of round-cell type were very difficult to diagnose by LM and could be demonstrated by EM depending on thevarying amount of cytoplasmic lipid,basal lamina,pinocytotic vesivles and small pools of glycogen.