肝硬变门脉高压大鼠应用汉防已甲素、丹参、心得安后胃粘膜超微结构的变化

THE ULTRASTRUCTURE OF GASTRIC MUCOSA IN PORTAL HYPERTENSIVE RATS AND THE CHANGES AFTER TETRANDRINE, SALVIA MILTIORRHIZAE AND PROPRANOLOL THERAPIES

本文用透射电镜观察肝硬变门脉高压大鼠胃粘膜,发现胃粘膜微循环障碍,毛细血管超微结构异常;上皮细胞和壁细胞超微结构破坏。经汉防己甲素、丹参、心得安治疗后各组的胃粘膜超微结构均趋于正常,上述病理改变消失。证明胃粘膜防御机制的破坏是门脉高压时胃粘膜病变发生的主要原因;汉防己甲素、丹参、心得安对门脉高压时的胃粘膜病变有防治作用。

The ultrastructure of gastric mucosa was observed by transmission electron microscope in drrhotic rats with portal hypertension (PUT), not treated and treated by separate use of tetrandrine, salvia miifiorrhizae and propraaolol. The experiments were stncly controlled. In the gastric mticosa of cirrhotic PUT rats, the capillaries were markedly dilated; the cytoplasm of eadothelial cells became very thin, the endothelial cells were damaged with blood plasma leaking out; blood stagnated in capillaries; and the interspace between capillaries and gland cells was extremely widened and dec-matous. The epithelial cells of the mucosa were transformed, with the orga-nelles destructed and secretion decreasedj the cell junctions were distorted becoming edema cavities. The secretory function of parietal cells decreased, with their organelies dissolved to form empty cavities. In contrast to these alterations, the ultrastructure of gastric mucosa in all of the cirrhotic PUT rats that received one of the 3 therapies, appeared to be normal. These results show that destruction of microcirculation and mucosal protective mechanism precipitates the gastric mucosal lesions ( GML ) , and that tetrandriae, salvia mikiorrhizae and propranolol are effective as treatment for PUT GML.